Assay Detail
Binding
CHEMBL3424258
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Inhibition of Leishmania CRK3/CYC6 using histone H1/[gamma33-P]ATP as substrate after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.44 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3423087 | — | — | 1 | 6.94 |
| CHEMBL3423080 | — | — | 1 | 6.79 |
| CHEMBL3423086 | — | — | 1 | 6.67 |
| CHEMBL3423075 | — | — | 1 | 6.50 |
| CHEMBL3423076 | — | — | 1 | 6.42 |
| CHEMBL1094304 | OLOMOUCINE II | — | 1 | 6.23 |
| CHEMBL2349189 | — | — | 1 | 6.19 |
| CHEMBL3423079 | — | — | 1 | 5.78 |
| CHEMBL3423090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3423087 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL3423080 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL3423086 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL3423075 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL3423076 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL1094304 | OLOMOUCINE II | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2349189 | — | IC50 | = | 641.0 | nM | 6.19 |
| CHEMBL3423079 | — | IC50 | = | 1648.0 | nM | 5.78 |
| CHEMBL3423090 | — | IC50 | - | — | - |