Assay Detail
Functional
CHEMBL3424261
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Leshmanicidal activity against promastigote stage of Leishmania donovani MHOM/SD/1962/1S-c12d at 30 uM after 72 hrs by alamar blue staining-based fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.72 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3423080 | — | — | 1 | 5.66 |
| CHEMBL3423079 | — | — | 1 | 4.91 |
| CHEMBL3423090 | — | — | 1 | 4.78 |
| CHEMBL1094304 | OLOMOUCINE II | — | 1 | 4.21 |
| CHEMBL2349189 | — | — | 1 | 4.02 |
| CHEMBL3423075 | — | — | 1 | - |
| CHEMBL3423076 | — | — | 1 | - |
| CHEMBL3423086 | — | — | 1 | - |
| CHEMBL3423087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3423080 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3423079 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3423090 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL1094304 | OLOMOUCINE II | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL2349189 | — | IC50 | = | 95900.0 | nM | 4.02 |
| CHEMBL3423075 | — | IC50 | - | — | - | |
| CHEMBL3423076 | — | IC50 | - | — | - | |
| CHEMBL3423086 | — | IC50 | - | — | - | |
| CHEMBL3423087 | — | IC50 | - | — | - |