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Assay Detail

CHEMBL3424481

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human CYP19 expressed in hamster fibroblast using 500 nM [1beta-3H] androstenedione as substrate by HPLC analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11β-Hydroxylase.
Hu Q, Kunde J, Hanke N, Hartmann RW.
Eur J Med Chem (2015) 96 : 139 -150
PubMed 25874338 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.40 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2165320 1 7.46
CHEMBL3421766 1 7.12
CHEMBL3421785 1 6.89
CHEMBL3421767 1 6.86
CHEMBL3421765 1 6.84
CHEMBL3421786 1 6.80
CHEMBL3421779 1 6.78
CHEMBL3421764 1 6.35
CHEMBL3421780 1 5.81
CHEMBL3421769 1 5.72
CHEMBL3421778 1 5.68
CHEMBL3421768 1 5.62
CHEMBL3421770 1 5.30
CHEMBL428780 1 -
CHEMBL2417553 1 -
CHEMBL934 METYRAPONE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2165320 IC50 = 35.0 nM 7.46
CHEMBL3421766 IC50 = 75.0 nM 7.12
CHEMBL3421785 IC50 = 128.0 nM 6.89
CHEMBL3421767 IC50 = 137.0 nM 6.86
CHEMBL3421765 IC50 = 146.0 nM 6.84
CHEMBL3421786 IC50 = 157.0 nM 6.80
CHEMBL3421779 IC50 = 165.0 nM 6.78
CHEMBL3421764 IC50 = 447.0 nM 6.35
CHEMBL3421780 IC50 = 1546.0 nM 5.81
CHEMBL3421769 IC50 = 1894.0 nM 5.72
CHEMBL3421778 IC50 = 2090.0 nM 5.68
CHEMBL3421768 IC50 = 2425.0 nM 5.62
CHEMBL3421770 IC50 = 4993.0 nM 5.30
CHEMBL428780 IC50 > 5000.0 nM -
CHEMBL2417553 IC50 > 5000.0 nM -
CHEMBL934 METYRAPONE IC50 > 5000.0 nM -