Assay Detail
Binding
CHEMBL3424618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of transglutaminase 2 (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-glutamine gamma-glutamyltransferase (CHEMBL2730) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.10 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3423198 | — | — | 1 | 8.02 |
| CHEMBL3423193 | — | — | 1 | 7.34 |
| CHEMBL3423194 | — | — | 1 | 7.32 |
| CHEMBL3423202 | — | — | 1 | 7.32 |
| CHEMBL3423195 | — | — | 1 | 7.30 |
| CHEMBL3423197 | — | — | 1 | 7.24 |
| CHEMBL3423200 | — | — | 1 | 7.06 |
| CHEMBL3423199 | — | — | 1 | 6.89 |
| CHEMBL3423192 | — | — | 1 | 6.82 |
| CHEMBL3423203 | — | — | 1 | 6.82 |
| CHEMBL3423196 | — | — | 1 | 5.96 |
| CHEMBL3423201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3423198 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL3423193 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3423194 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3423202 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3423195 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3423197 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3423200 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3423199 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3423192 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3423203 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3423196 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3423201 | — | IC50 | - | — | - |