Assay Detail
Binding
CHEMBL3424809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from rat alpha7 nAChR transfected in HEK293 cells by liquid scintillation counting
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 6.13 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082655 | — | — | 1 | 8.23 |
| CHEMBL3422597 | — | — | 1 | 7.47 |
| CHEMBL3422581 | — | — | 1 | 7.07 |
| CHEMBL3422596 | — | — | 1 | 6.85 |
| CHEMBL3422567 | — | — | 1 | 6.72 |
| CHEMBL565963 | — | — | 1 | 6.66 |
| CHEMBL3422582 | — | — | 1 | 6.51 |
| CHEMBL3422579 | — | — | 1 | 6.48 |
| CHEMBL3422580 | — | — | 1 | 6.46 |
| CHEMBL3422574 | — | — | 1 | 6.39 |
| CHEMBL3422585 | — | — | 1 | 6.18 |
| CHEMBL1084615 | — | — | 1 | 6.17 |
| CHEMBL3422573 | — | — | 1 | 5.85 |
| CHEMBL3422568 | — | — | 1 | 5.79 |
| CHEMBL3422584 | — | — | 1 | 5.58 |
| CHEMBL3422570 | — | — | 1 | 5.50 |
| CHEMBL1194009 | — | — | 1 | 5.39 |
| CHEMBL3422576 | — | — | 1 | 5.27 |
| CHEMBL3422578 | — | — | 1 | 5.21 |
| CHEMBL3422595 | — | — | 1 | 5.11 |
| CHEMBL568464 | — | — | 1 | 5.03 |
| CHEMBL3422594 | — | — | 1 | 5.03 |
| CHEMBL3422588 | — | — | 1 | - |
| CHEMBL3422593 | — | — | 1 | - |
| CHEMBL3422592 | — | — | 1 | - |
| CHEMBL3422591 | — | — | 1 | - |
| CHEMBL3422590 | — | — | 1 | - |
| CHEMBL3422589 | — | — | 1 | - |
| CHEMBL3422587 | — | — | 1 | - |
| CHEMBL3422586 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082655 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL3422597 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3422581 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL3422596 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3422567 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL565963 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3422582 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3422579 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL3422580 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL3422574 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL3422585 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL1084615 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL3422573 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3422568 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL3422584 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3422570 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL1194009 | — | Ki | = | 4070.0 | nM | 5.39 |
| CHEMBL3422576 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL3422578 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL3422595 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL568464 | — | Ki | = | 9330.0 | nM | 5.03 |
| CHEMBL3422594 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL3422577 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422575 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422569 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422572 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422583 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422571 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422586 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422587 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422589 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422590 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422591 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422592 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422593 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422588 | — | Ki | > | 10000.0 | nM | - |