Assay Detail
Binding
CHEMBL3424810
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Displacement of [3H]epibatidine from rat alpha4beta2 nAChR transfected in HEK293 cells by liquid scintillation counting
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 6.38 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1194009 | — | — | 1 | 6.38 |
| CHEMBL3422595 | — | — | 1 | - |
| CHEMBL3422575 | — | — | 1 | - |
| CHEMBL3422574 | — | — | 1 | - |
| CHEMBL1084615 | — | — | 1 | - |
| CHEMBL3422572 | — | — | 1 | - |
| CHEMBL3422571 | — | — | 1 | - |
| CHEMBL3422570 | — | — | 1 | - |
| CHEMBL3422569 | — | — | 1 | - |
| CHEMBL3422568 | — | — | 1 | - |
| CHEMBL568464 | — | — | 1 | - |
| CHEMBL3422567 | — | — | 1 | - |
| CHEMBL565963 | — | — | 1 | - |
| CHEMBL3422573 | — | — | 1 | - |
| CHEMBL3422597 | — | — | 1 | - |
| CHEMBL3422596 | — | — | 1 | - |
| CHEMBL3422594 | — | — | 1 | - |
| CHEMBL3422593 | — | — | 1 | - |
| CHEMBL3422592 | — | — | 1 | - |
| CHEMBL3422591 | — | — | 1 | - |
| CHEMBL3422590 | — | — | 1 | - |
| CHEMBL3422582 | — | — | 1 | - |
| CHEMBL1082655 | — | — | 1 | - |
| CHEMBL3422588 | — | — | 1 | - |
| CHEMBL3422587 | — | — | 1 | - |
| CHEMBL3422586 | — | — | 1 | - |
| CHEMBL3422585 | — | — | 1 | - |
| CHEMBL3422584 | — | — | 1 | - |
| CHEMBL3422583 | — | — | 1 | - |
| CHEMBL3422589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1194009 | — | Ki | = | 417.0 | nM | 6.38 |
| CHEMBL1084615 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL565963 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422567 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL568464 | — | Ki | - | — | - | |
| CHEMBL3422568 | — | Ki | - | — | - | |
| CHEMBL3422569 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422570 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422571 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422572 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422573 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422574 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422575 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422576 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422577 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422578 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422579 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422580 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422581 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422582 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422589 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422583 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422584 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422585 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3422586 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422587 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3422588 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1082655 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL3422597 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422590 | — | Ki | - | — | - | |
| CHEMBL3422591 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422592 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422593 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422594 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422595 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3422596 | — | Ki | > | 10000.0 | nM | - |