Assay Detail
Binding
CHEMBL3424812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by fluorescent calcium assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | GH4-C1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.49 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082655 | — | — | 1 | 7.60 |
| CHEMBL3422596 | — | — | 1 | 6.90 |
| CHEMBL3422581 | — | — | 1 | 6.84 |
| CHEMBL3422597 | — | — | 1 | 6.60 |
| CHEMBL3422580 | — | — | 1 | 6.28 |
| CHEMBL1084615 | — | — | 1 | 6.16 |
| CHEMBL3422582 | — | — | 1 | 6.00 |
| CHEMBL576234 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082655 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3422596 | — | EC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3422581 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL3422597 | — | EC50 | = | 253.0 | nM | 6.60 |
| CHEMBL3422580 | — | EC50 | = | 522.0 | nM | 6.28 |
| CHEMBL1084615 | — | EC50 | = | 687.0 | nM | 6.16 |
| CHEMBL3422582 | — | EC50 | = | 997.0 | nM | 6.00 |
| CHEMBL576234 | — | EC50 | = | 2840.0 | nM | 5.55 |