Assay Detail
Binding
CHEMBL3424813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by patch-clamp electrophysiology assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | GH4-C1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.47 | 4.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422581 | — | — | 1 | 4.56 |
| CHEMBL1084615 | — | — | 1 | 4.38 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422581 | — | EC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL1084615 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 127600.0 | nM | - |