Assay Detail
Binding
CHEMBL3424959
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Inhibition of Wistar rat kidney aldehyde reductase using D-glucuronate as substrate by spectrophotometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B7 (CHEMBL3421523) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.86 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 7.31 |
| CHEMBL3422326 | — | — | 1 | 5.32 |
| CHEMBL3422329 | — | — | 1 | 4.85 |
| CHEMBL3422332 | — | — | 1 | 4.71 |
| CHEMBL1984484 | — | — | 1 | 4.61 |
| CHEMBL1405739 | — | — | 1 | 4.39 |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | 4.25 |
| CHEMBL1337856 | — | — | 1 | 4.17 |
| CHEMBL1333950 | — | — | 1 | 4.10 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | - |
| CHEMBL3422334 | — | — | 1 | - |
| CHEMBL3422333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3422326 | — | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL3422329 | — | IC50 | = | 14130.0 | nM | 4.85 |
| CHEMBL3422332 | — | IC50 | = | 19560.0 | nM | 4.71 |
| CHEMBL1984484 | — | IC50 | = | 24790.0 | nM | 4.61 |
| CHEMBL1405739 | — | IC50 | = | 40550.0 | nM | 4.39 |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL1337856 | — | IC50 | = | 68440.0 | nM | 4.17 |
| CHEMBL1333950 | — | IC50 | = | 80160.0 | nM | 4.10 |
| CHEMBL56337 | EPALRESTAT | IC50 | - | — | - | |
| CHEMBL3422334 | — | IC50 | - | — | - | |
| CHEMBL3422333 | — | IC50 | - | — | - |