Assay Detail
Binding
CHEMBL3424975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse melanocortin-1 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Melanocyte-stimulating hormone receptor (CHEMBL4077) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.27 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | — | 1 | 9.66 |
| CHEMBL3422426 | — | — | 1 | 9.17 |
| CHEMBL264190 | — | — | 1 | 7.15 |
| CHEMBL3422427 | — | — | 1 | 5.70 |
| CHEMBL3422430 | — | — | 1 | 5.57 |
| CHEMBL3422432 | — | — | 1 | 5.26 |
| CHEMBL3422433 | — | — | 1 | 5.24 |
| CHEMBL3422431 | — | — | 1 | 5.19 |
| CHEMBL3422429 | — | — | 1 | 5.08 |
| CHEMBL3422428 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | EC50 | = | 0.22 | nM | 9.66 |
| CHEMBL3422426 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL264190 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3422427 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3422430 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3422432 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3422433 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3422431 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3422429 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3422428 | — | EC50 | = | 20700.0 | nM | 4.68 |