Assay Detail
Binding
CHEMBL3425007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-SB222200 from monkey NK3R after 90 mins by scintillation counting analysis
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca mulatta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.02 | 8.40 |
| pKi | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422009 | — | — | 1 | 8.40 |
| CHEMBL3422015 | — | — | 1 | 8.20 |
| CHEMBL3422018 | — | — | 1 | 8.20 |
| CHEMBL3422010 | — | — | 1 | 7.70 |
| CHEMBL3422017 | — | — | 1 | 7.60 |
| CHEMBL437797 | NEUROKININ B | — | 1 | - |
| CHEMBL106124 | SENKTIDE | — | 1 | - |
| CHEMBL346178 | OSANETANT | 2.0 | 1 | - |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422009 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL3422015 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL3422018 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL3422010 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL3422017 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL437797 | NEUROKININ B | pKi | - | — | - | |
| CHEMBL106124 | SENKTIDE | pKi | - | — | - | |
| CHEMBL346178 | OSANETANT | pKi | - | — | - | |
| CHEMBL10188 | TALNETANT | pKi | - | — | - |