Assay Detail
Binding
CHEMBL3425009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.49 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 6.40 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 6.30 |
| CHEMBL3422009 | — | — | 1 | 5.90 |
| CHEMBL3422015 | — | — | 1 | 5.10 |
| CHEMBL3422010 | — | — | 1 | 4.90 |
| CHEMBL3422018 | — | — | 1 | 4.90 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 4.90 |
| CHEMBL106124 | SENKTIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL437797 | NEUROKININ B | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL3422009 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL3422015 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL3422010 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL3422018 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL10188 | TALNETANT | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL106124 | SENKTIDE | Ki | > | 10000.0 | nM | - |