Assay Detail
Binding
CHEMBL3425019
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Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.19 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | — | 1 | 9.24 |
| CHEMBL3422426 | — | — | 1 | 8.62 |
| CHEMBL264190 | — | — | 1 | 8.34 |
| CHEMBL3422431 | — | — | 1 | 5.75 |
| CHEMBL3422427 | — | — | 1 | 5.55 |
| CHEMBL3422430 | — | — | 1 | 5.28 |
| CHEMBL3422428 | — | — | 1 | 5.11 |
| CHEMBL3422433 | — | — | 1 | 4.71 |
| CHEMBL3422432 | — | — | 1 | 4.69 |
| CHEMBL3422429 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | EC50 | = | 0.57 | nM | 9.24 |
| CHEMBL3422426 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL264190 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3422431 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3422427 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3422430 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3422428 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3422433 | — | EC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL3422432 | — | EC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL3422429 | — | EC50 | = | 23700.0 | nM | 4.62 |