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Assay Detail

CHEMBL3425152

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Binding
Antagonist activity at Pseudomonas aeruginosa LasR expressed in Escherichia coli BL21 DE3 after 4 to 6 hrs by GFP reporter gene assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pseudomonas aeruginosa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa.
O'Brien KT, Noto JG, Nichols-O'Neill L, Perez LJ.
ACS Med Chem Lett (2015) 6 : 162 -167
PubMed 25699144 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.58 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3421669 1 5.82
CHEMBL3421666 1 5.44
CHEMBL575294 1 4.79
CHEMBL3421668 1 4.29
CHEMBL3421664 1 4.13
CHEMBL3421667 1 4.11
CHEMBL3421665 1 4.06
CHEMBL3421633 1 4.00
CHEMBL3421671 1 -
CHEMBL3421670 1 -
CHEMBL3421663 1 -
CHEMBL3421662 1 -
CHEMBL3422509 1 -
CHEMBL3422508 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3421669 IC50 = 1500.0 nM 5.82
CHEMBL3421666 IC50 = 3600.0 nM 5.44
CHEMBL575294 IC50 = 16400.0 nM 4.79
CHEMBL3421668 IC50 = 51900.0 nM 4.29
CHEMBL3421664 IC50 = 73800.0 nM 4.13
CHEMBL3421667 IC50 = 78100.0 nM 4.11
CHEMBL3421665 IC50 = 86800.0 nM 4.06
CHEMBL3421633 IC50 = 99500.0 nM 4.00
CHEMBL3421671 IC50 > 100000.0 nM -
CHEMBL3421670 IC50 > 100000.0 nM -
CHEMBL3421663 IC50 = 145000.0 nM -
CHEMBL3421662 IC50 > 200000.0 nM -
CHEMBL3422509 IC50 > 200000.0 nM -
CHEMBL3422508 IC50 = 148000.0 nM -