Assay Detail
Binding
CHEMBL3425159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Pseudomonas aeruginosa LasR expressed in Escherichia coli BL21 DE3 after 4 to 6 hrs by GFP reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LasR (CHEMBL1075207) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.68 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3421671 | — | — | 1 | 8.44 |
| CHEMBL3421670 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3421671 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3421670 | — | EC50 | = | 119.0 | nM | 6.92 |