Assay Detail
Binding
CHEMBL3427867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human immunodeficiency virus-1 reverse transcriptase associated RNase H activity using using 18-nucleotide 3,-fluorescein-labeled RNA substrate by fluorescence resonance energy transfer assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Sesquiterpenoid tropolone glycosides from Liriosma ovata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.53 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550937 | BETA-THUJAPLICINOL | — | 1 | 6.58 |
| CHEMBL3426555 | — | — | 1 | 4.47 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | - |
| CHEMBL3426556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550937 | BETA-THUJAPLICINOL | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3426555 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL853 | ZALCITABINE | IC50 | - | — | - | |
| CHEMBL3426556 | — | IC50 | > | 50000.0 | nM | - |