Assay Detail
Physicochemical
CHEMBL3427880
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Metal chelating activity of the compound assessed as zinc complex formation after 5 mins by EGTA fluorescence titration Assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Physicochemical |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.83 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426429 | — | — | 1 | 8.97 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 8.89 |
| CHEMBL3426431 | — | — | 1 | 8.86 |
| CHEMBL3426440 | — | — | 1 | 8.86 |
| CHEMBL3426407 | — | — | 1 | 8.84 |
| CHEMBL3426403 | — | — | 1 | 8.56 |
| CHEMBL572505 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426429 | — | Kd | = | 1.07 | nM | 8.97 |
| CHEMBL591429 | PAC-1 | Kd | = | 1.28 | nM | 8.89 |
| CHEMBL3426431 | — | Kd | = | 1.37 | nM | 8.86 |
| CHEMBL3426440 | — | Kd | = | 1.37 | nM | 8.86 |
| CHEMBL3426407 | — | Kd | = | 1.46 | nM | 8.84 |
| CHEMBL3426403 | — | Kd | = | 2.72 | nM | 8.56 |
| CHEMBL572505 | — | Kd | > | 1000000.0 | nM | - |