Assay Detail
Functional
CHEMBL3427890
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse EL4 cells assessed as cell death after 72 hrs by sulforhodamine B assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | EL4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.21 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426440 | — | — | 1 | 5.33 |
| CHEMBL3426431 | — | — | 1 | 5.29 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.19 |
| CHEMBL3426407 | — | — | 1 | 5.19 |
| CHEMBL3426429 | — | — | 1 | 5.14 |
| CHEMBL3426403 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426440 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3426431 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL591429 | PAC-1 | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3426407 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3426429 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3426403 | — | IC50 | = | 7900.0 | nM | 5.10 |