Assay Detail
Functional
CHEMBL3428183
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Antiviral activity against Hepatitis C virus J6/JFH infected in human Huh7.5 cells assessed as inhibition of viral replication measured after 72 hrs by luciferase reporter gene assay
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.81 | 6.30 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.30 |
| CHEMBL3425865 | — | — | 2 | 5.59 |
| CHEMBL3425867 | — | — | 2 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3425865 | — | EC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL3425867 | — | EC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL3425865 | — | Inhibition | - | % | - | |
| CHEMBL3425867 | — | Inhibition | - | % | - |