Assay Detail
Binding
CHEMBL3428283
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Inhibition of LCK (unknown origin)
17
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.21 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426301 | — | — | 2 | 6.68 |
| CHEMBL3426302 | — | — | 2 | 6.62 |
| CHEMBL3426308 | — | — | 1 | 6.58 |
| CHEMBL3298371 | — | — | 1 | 6.47 |
| CHEMBL3426309 | — | — | 1 | 6.34 |
| CHEMBL3426304 | — | — | 1 | 6.22 |
| CHEMBL3426307 | — | — | 1 | 6.22 |
| CHEMBL3426303 | — | — | 2 | 6.19 |
| CHEMBL3426305 | — | — | 2 | 6.18 |
| CHEMBL3298369 | — | — | 1 | 5.85 |
| CHEMBL3298374 | — | — | 1 | 5.75 |
| CHEMBL3298288 | — | — | 1 | 5.75 |
| CHEMBL3426306 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426301 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3426302 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3426308 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3426301 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3298371 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL3426309 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL3426304 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL3426307 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL3426303 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL3426305 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL3426302 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3298369 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3426305 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3298288 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3298374 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3426303 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL3426306 | — | Ki | > | 2500.0 | nM | - |