Assay Detail
Binding
CHEMBL3428359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CHEMBL4660) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 84 | 6.51 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426065 | — | — | 1 | 8.85 |
| CHEMBL3426064 | — | — | 1 | 8.47 |
| CHEMBL3426037 | — | — | 1 | 8.42 |
| CHEMBL3426033 | — | — | 1 | 8.41 |
| CHEMBL3426066 | — | — | 1 | 8.32 |
| CHEMBL3426067 | — | — | 1 | 8.28 |
| CHEMBL3426032 | — | — | 1 | 8.22 |
| CHEMBL3426034 | — | — | 1 | 8.14 |
| CHEMBL3426035 | — | — | 1 | 8.00 |
| CHEMBL3426038 | — | — | 1 | 7.89 |
| CHEMBL3426040 | — | — | 1 | 7.85 |
| CHEMBL3426039 | — | — | 1 | 7.82 |
| CHEMBL3426058 | — | — | 1 | 7.58 |
| CHEMBL3426057 | — | — | 1 | 7.55 |
| CHEMBL3426061 | — | — | 1 | 7.38 |
| CHEMBL3426188 | — | — | 1 | 7.31 |
| CHEMBL3426063 | — | — | 1 | 7.30 |
| CHEMBL3426060 | — | — | 1 | 7.28 |
| CHEMBL3426031 | — | — | 1 | 7.28 |
| CHEMBL3426036 | — | — | 1 | 7.27 |
| CHEMBL3426029 | — | — | 1 | 7.26 |
| CHEMBL3426027 | — | — | 1 | 7.24 |
| CHEMBL3426028 | — | — | 1 | 7.21 |
| CHEMBL3426059 | — | — | 1 | 7.19 |
| CHEMBL3426191 | — | — | 1 | 7.11 |
| CHEMBL3426030 | — | — | 1 | 7.05 |
| CHEMBL3426193 | — | — | 1 | 7.04 |
| CHEMBL3426186 | — | — | 1 | 6.93 |
| CHEMBL3426094 | — | — | 1 | 6.88 |
| CHEMBL3426187 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426065 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3426064 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3426037 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3426033 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3426066 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3426067 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3426032 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3426034 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3426035 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3426038 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3426040 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3426039 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3426058 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3426057 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3426061 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3426188 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3426063 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3426060 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3426031 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3426036 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3426029 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3426027 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3426028 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3426059 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3426191 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3426030 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3426193 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3426186 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3426094 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL3426187 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3426189 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL3426184 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL3426056 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL3426062 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL3426055 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL3426093 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL3426068 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL3426190 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL3426086 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3426043 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL3426084 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3426081 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3426072 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3426085 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3426069 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3426090 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3426044 | — | IC50 | = | 959.0 | nM | 6.02 |
| CHEMBL3426082 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3426192 | — | IC50 | = | 971.0 | nM | 6.01 |
| CHEMBL3426075 | — | IC50 | = | 970.0 | nM | 6.01 |