Assay Detail
ADMET
CHEMBL3428434
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Cytotoxicity against hepatocytes (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Not specified |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.65 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298371 | — | — | 1 | 5.21 |
| CHEMBL3426305 | — | — | 1 | 4.08 |
| CHEMBL3426308 | — | — | 1 | - |
| CHEMBL3426309 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298371 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3426305 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL3426308 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3426309 | — | IC50 | > | 100000.0 | nM | - |