Assay Detail
Binding
CHEMBL3428579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NF-kappaB (unknown origin) transcriptional activity in LPS-induced mouse RAW264.7 cells after 1 hr by secreted alkaline phosphatase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RAW264.7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Nuclear factor NF-kappa-B complex (CHEMBL2094258) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents and inhibitors of NF-κB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.50 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3427309 | — | — | 1 | 4.64 |
| CHEMBL3427431 | — | — | 1 | 4.47 |
| CHEMBL399491 | PYRROLIDINE DITHIOCARBAMATE | — | 1 | 4.46 |
| CHEMBL192694 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3427309 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3427431 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL399491 | PYRROLIDINE DITHIOCARBAMATE | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL192694 | — | IC50 | = | 37200.0 | nM | 4.43 |