Assay Detail
Binding
CHEMBL3429150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LCK using peptide poly[Glu:Tyr] (4:1) substrate by 33P Hotspot assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel ACK1/TNK2 inhibitors using a fragment-based approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.33 | 8.22 |
| Ki | 1 | 6.86 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247479 | — | — | 1 | 8.22 |
| CHEMBL247070 | — | — | 1 | 6.91 |
| CHEMBL3426891 | — | — | 1 | 6.87 |
| CHEMBL2087874 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247479 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL247070 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL3426891 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL2087874 | — | Ki | = | 138.0 | nM | 6.86 |