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Assay Detail

CHEMBL3429253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of His6-tagged UBLCP1 (unknown origin) expressed in Escherichia coli BL21 cells by Lineweaver-Burk plot analysis in presence of pNPP
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BL21
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Ubiquitin-like domain-containing CTD phosphatase 1 (CHEMBL3317333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.
He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY.
Bioorg Med Chem (2015) 23 : 2798 -2809
PubMed 25907364 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.00 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3426913 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3426913 Ki = 1000.0 nM 6.00