Assay Detail
Binding
CHEMBL3429403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant VEGFR1 (unknown origin) by cell-free assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of deuterated Tivozanib for improving pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.08 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289494 | TIVOZANIB | 4.0 | 1 | 8.20 |
| CHEMBL3426917 | — | — | 1 | 7.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289494 | TIVOZANIB | IC50 | = | 6.26 | nM | 8.20 |
| CHEMBL3426917 | — | IC50 | = | 11.2 | nM | 7.95 |