Assay Detail
Binding
CHEMBL3429522
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Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.29 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3425764 | — | — | 1 | 7.92 |
| CHEMBL1688383 | — | — | 1 | 7.72 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.70 |
| CHEMBL3425765 | — | — | 1 | 6.77 |
| CHEMBL3425828 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3425764 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1688383 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1023 | BEXAROTENE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3425765 | — | EC50 | = | 169.0 | nM | 6.77 |
| CHEMBL3425828 | — | EC50 | = | 450.0 | nM | 6.35 |