Assay Detail
Functional
CHEMBL3429863
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Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.07 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426225 | — | — | 1 | 7.96 |
| CHEMBL3426233 | — | — | 1 | 7.85 |
| CHEMBL3426229 | — | — | 1 | 7.80 |
| CHEMBL3426224 | — | — | 1 | 7.70 |
| CHEMBL3426230 | — | — | 1 | 7.66 |
| CHEMBL3426234 | — | — | 1 | 7.62 |
| CHEMBL3426226 | — | — | 1 | 7.55 |
| CHEMBL3425518 | — | — | 1 | 7.40 |
| CHEMBL3426232 | — | — | 1 | 7.30 |
| CHEMBL3426223 | — | — | 1 | 7.30 |
| CHEMBL3426228 | — | — | 1 | 7.29 |
| CHEMBL3426235 | — | — | 1 | 7.28 |
| CHEMBL3426222 | — | — | 1 | 7.25 |
| CHEMBL3426219 | — | — | 1 | 7.24 |
| CHEMBL3426227 | — | — | 1 | 7.19 |
| CHEMBL3426217 | — | — | 1 | 7.16 |
| CHEMBL3426220 | — | — | 1 | 6.99 |
| CHEMBL3426231 | — | — | 1 | 6.84 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.81 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.75 |
| CHEMBL3426218 | — | — | 1 | 6.57 |
| CHEMBL3426239 | — | — | 1 | 6.49 |
| CHEMBL3426236 | — | — | 1 | 6.38 |
| CHEMBL3426237 | — | — | 1 | 5.91 |
| CHEMBL3426221 | — | — | 1 | 5.82 |
| CHEMBL3426238 | — | — | 1 | 5.76 |
| CHEMBL3426240 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426225 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3426233 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3426229 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3426224 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3426230 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3426234 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3426226 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3425518 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3426232 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3426223 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3426228 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3426235 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3426222 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3426219 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3426227 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3426217 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3426220 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL3426231 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3426218 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3426239 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL3426236 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL3426237 | — | IC50 | = | 1225.0 | nM | 5.91 |
| CHEMBL3426221 | — | IC50 | = | 1515.0 | nM | 5.82 |
| CHEMBL3426238 | — | IC50 | = | 1743.0 | nM | 5.76 |
| CHEMBL3426240 | — | IC50 | > | 5000.0 | nM | - |