Assay Detail
Functional
CHEMBL3429914
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Inhibition of cell proliferation in human MCF7 cells after 7 days by laser scanning imaging cytometer analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.29 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3427401 | — | — | 1 | 8.35 |
| CHEMBL3427415 | — | — | 1 | 7.70 |
| CHEMBL3427385 | — | — | 1 | 6.58 |
| CHEMBL33899 | — | — | 1 | 6.52 |
| CHEMBL3427402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3427401 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3427415 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3427385 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL33899 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3427402 | — | EC50 | < | 0.1 | nM | - |