Assay Detail
Functional
CHEMBL3430562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWorks Quattro automated patch clamp platform
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
A-type voltage-gated potassium channel KCND3 (CHEMBL1964) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Prediction of Thorough QT study results using action potential simulations based on ion channel screens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.30 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1734 | SOLIFENACIN | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1734 | SOLIFENACIN | IC50 | = | 50118.72 | nM | 4.30 |