Assay Detail

CHEMBL3430573

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Functional

Inhibition of Na channel (species unknown)

ChEMBL ↗

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Target

Sodium channel alpha subunit (CHEMBL2331043) ↗

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Primary target Sodium channel alpha subunit

CHEMBL2331043

Anchored from Assay target.

Protein identity Sodium channel alpha subunit

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Confidence	4 — Cell-line / Tissue
Curated By	Autocuration

Target

Sodium channel alpha subunit (CHEMBL2331043) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Mirams GR, Cui Y, Sher A, Fink M, Cooper J, Heath BM, McMahon NC, Gavaghan DJ, Noble D.
Cardiovasc Res (2011) 91 : 53 -61
PubMed 21300721 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.11	5.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL87045	CIFENLINE	2.0	1	5.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL87045	CIFENLINE	IC50	=	7800.0	nM	5.11