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Assay Detail

CHEMBL3431933

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Binding
SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform
ChEMBL ↗
476
Total Activities
476
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carnitine O-palmitoyltransferase 1, liver isoform (CHEMBL1293194) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Roche carnitine palmitoyltransferase modulator screening data (supplementary data associated with the publication CHEMBL2216752).

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 476 6.97 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3431816 — — 1 8.15
CHEMBL3431624 — — 1 7.94
CHEMBL3431814 — — 1 7.89
CHEMBL3431540 — — 1 7.88
CHEMBL3431837 — — 1 7.83
CHEMBL3431830 — — 1 7.82
CHEMBL2216778 — — 1 7.79
CHEMBL3431629 — — 1 7.78
CHEMBL3431752 — — 1 7.78
CHEMBL3431919 — — 1 7.76
CHEMBL3431533 — — 1 7.73
CHEMBL3431642 — — 1 7.73
CHEMBL3431807 — — 1 7.71
CHEMBL2216774 — — 1 7.71
CHEMBL3431820 — — 1 7.71
CHEMBL3431514 — — 1 7.70
CHEMBL2216779 — — 1 7.69
CHEMBL3431845 — — 1 7.68
CHEMBL3431634 — — 1 7.66
CHEMBL3431627 — — 1 7.65
CHEMBL3431678 — — 1 7.65
CHEMBL3431512 — — 1 7.62
CHEMBL3431560 — — 1 7.61
CHEMBL3431808 — — 1 7.60
CHEMBL3431542 — — 1 7.58
CHEMBL3431672 — — 1 7.58
CHEMBL3431535 — — 1 7.57
CHEMBL3431842 — — 1 7.57
CHEMBL3431675 — — 1 7.55
CHEMBL3431503 — — 1 7.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3431816 — IC50 = 7.1 nM 8.15
CHEMBL3431624 — IC50 = 11.6 nM 7.94
CHEMBL3431814 — IC50 = 12.8 nM 7.89
CHEMBL3431540 — IC50 = 13.2 nM 7.88
CHEMBL3431837 — IC50 = 14.7 nM 7.83
CHEMBL3431830 — IC50 = 15.15 nM 7.82
CHEMBL2216778 — IC50 = 16.2 nM 7.79
CHEMBL3431752 — IC50 = 16.7 nM 7.78
CHEMBL3431629 — IC50 = 16.7 nM 7.78
CHEMBL3431919 — IC50 = 17.5 nM 7.76
CHEMBL3431533 — IC50 = 18.6 nM 7.73
CHEMBL3431642 — IC50 = 18.8 nM 7.73
CHEMBL2216774 — IC50 = 19.6 nM 7.71
CHEMBL3431807 — IC50 = 19.65 nM 7.71
CHEMBL3431820 — IC50 = 19.3 nM 7.71
CHEMBL3431514 — IC50 = 20.1 nM 7.70
CHEMBL2216779 — IC50 = 20.6 nM 7.69
CHEMBL3431845 — IC50 = 20.8 nM 7.68
CHEMBL3431634 — IC50 = 21.9 nM 7.66
CHEMBL3431627 — IC50 = 22.3 nM 7.65
CHEMBL3431678 — IC50 = 22.6 nM 7.65
CHEMBL3431512 — IC50 = 23.9 nM 7.62
CHEMBL3431560 — IC50 = 24.6 nM 7.61
CHEMBL3431808 — IC50 = 25.0 nM 7.60
CHEMBL3431542 — IC50 = 26.05 nM 7.58
CHEMBL3431672 — IC50 = 26.4 nM 7.58
CHEMBL3431535 — IC50 = 26.7 nM 7.57
CHEMBL3431842 — IC50 = 27.0 nM 7.57
CHEMBL3431675 — IC50 = 27.9 nM 7.55
CHEMBL3431503 — IC50 = 29.2 nM 7.54
CHEMBL3431628 — IC50 = 29.4 nM 7.53
CHEMBL3431504 — IC50 = 30.0 nM 7.52
CHEMBL3431622 — IC50 = 31.2 nM 7.51
CHEMBL3431789 — IC50 = 31.0 nM 7.51
CHEMBL3431475 — IC50 = 32.6 nM 7.49
CHEMBL3431851 — IC50 = 32.6 nM 7.49
CHEMBL3431841 — IC50 = 33.7 nM 7.47
CHEMBL3431518 — IC50 = 34.2 nM 7.47
CHEMBL3431806 — IC50 = 33.5 nM 7.47
CHEMBL3431515 — IC50 = 34.2 nM 7.47
CHEMBL3431502 — IC50 = 34.4 nM 7.46
CHEMBL3431704 — IC50 = 34.5 nM 7.46
CHEMBL3431578 — IC50 = 35.6 nM 7.45
CHEMBL3431630 — IC50 = 35.3 nM 7.45
CHEMBL3431537 — IC50 = 35.4 nM 7.45
CHEMBL3431631 — IC50 = 35.8 nM 7.45
CHEMBL3431591 — IC50 = 36.4 nM 7.44
CHEMBL3431815 — IC50 = 36.1 nM 7.44
CHEMBL3431539 — IC50 = 37.0 nM 7.43
CHEMBL3431499 — IC50 = 36.7 nM 7.43