Assay Detail
Functional
CHEMBL3436040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro
792
Total Activities
791
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania mexicana |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
St. Jude Leishmania screening dataset.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 792 | 5.46 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592105 | METHYLROSANILINE | -1.0 | 1 | 7.36 |
| CHEMBL547470 | DIHYDROEMETINE | — | 1 | 7.20 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.09 |
| CHEMBL535077 | — | — | 1 | 7.02 |
| CHEMBL526110 | — | — | 1 | 6.89 |
| CHEMBL532464 | — | — | 1 | 6.84 |
| CHEMBL535750 | — | — | 1 | 6.80 |
| CHEMBL581702 | — | — | 1 | 6.78 |
| CHEMBL588259 | — | — | 1 | 6.75 |
| CHEMBL581135 | — | — | 1 | 6.68 |
| CHEMBL423192 | ANISOMYCIN | — | 1 | 6.65 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 6.62 |
| CHEMBL587029 | — | — | 1 | 6.62 |
| CHEMBL587153 | — | — | 1 | 6.61 |
| CHEMBL525149 | — | — | 1 | 6.49 |
| CHEMBL580914 | — | — | 1 | 6.42 |
| CHEMBL593052 | — | — | 1 | 6.41 |
| CHEMBL530291 | — | — | 1 | 6.41 |
| CHEMBL587120 | — | — | 1 | 6.38 |
| CHEMBL580307 | — | — | 1 | 6.34 |
| CHEMBL580918 | — | — | 1 | 6.33 |
| CHEMBL526243 | — | — | 1 | 6.27 |
| CHEMBL593290 | — | — | 1 | 6.26 |
| CHEMBL468963 | GW779439X | — | 1 | 6.25 |
| CHEMBL536166 | — | — | 1 | 6.22 |
| CHEMBL535741 | — | — | 1 | 6.21 |
| CHEMBL532650 | — | — | 1 | 6.21 |
| CHEMBL536115 | — | — | 1 | 6.19 |
| CHEMBL546522 | — | — | 1 | 6.19 |
| CHEMBL531170 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592105 | METHYLROSANILINE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL547470 | DIHYDROEMETINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL50588 | EMETINE | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL535077 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL526110 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL532464 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL535750 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL581702 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL588259 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL581135 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL423192 | ANISOMYCIN | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL587029 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL587153 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL525149 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL580914 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL593052 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL530291 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL587120 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL580307 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL580918 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL526243 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL593290 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL468963 | GW779439X | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL536166 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL535741 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL532650 | — | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL536115 | — | IC50 | = | 647.0 | nM | 6.19 |
| CHEMBL546522 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL531170 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL170760 | — | IC50 | = | 693.0 | nM | 6.16 |
| CHEMBL547077 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL535475 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL587090 | — | IC50 | = | 766.0 | nM | 6.12 |
| CHEMBL532472 | — | IC50 | = | 755.0 | nM | 6.12 |
| CHEMBL528849 | — | IC50 | = | 751.0 | nM | 6.12 |
| CHEMBL587612 | — | IC50 | = | 769.0 | nM | 6.11 |
| CHEMBL582042 | — | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL529140 | — | IC50 | = | 844.0 | nM | 6.07 |
| CHEMBL536112 | — | IC50 | = | 867.0 | nM | 6.06 |
| CHEMBL353621 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL526210 | — | IC50 | = | 949.0 | nM | 6.02 |
| CHEMBL579467 | — | IC50 | = | 976.0 | nM | 6.01 |
| CHEMBL529792 | — | IC50 | = | 1009.0 | nM | 6.00 |
| CHEMBL532254 | — | IC50 | = | 1026.0 | nM | 5.99 |
| CHEMBL586298 | — | IC50 | = | 1073.0 | nM | 5.97 |
| CHEMBL581791 | — | IC50 | = | 1101.0 | nM | 5.96 |
| CHEMBL514409 | HESPERADIN | IC50 | = | 1114.0 | nM | 5.95 |
| CHEMBL547552 | — | IC50 | = | 1142.0 | nM | 5.94 |
| CHEMBL580539 | — | IC50 | = | 1137.0 | nM | 5.94 |