Assay Detail
ADMET
CHEMBL3529889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of OATP2B1 (unknown origin) expressed in MDCK2 cells assessed as reduction of [3H]estrone-3-sulfate uptake after 3 mins by beta-counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MDCK-II |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 2B1 (CHEMBL1743124) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.63 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592675 | SILYBIN B | — | 1 | 6.10 |
| CHEMBL4802105 | SILICRISTIN | 2.0 | 1 | 5.44 |
| CHEMBL431701 | SILYBIN A | 3.0 | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592675 | SILYBIN B | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4802105 | SILICRISTIN | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL431701 | SILYBIN A | IC50 | = | 4500.0 | nM | 5.35 |