Assay Detail
ADMET
CHEMBL3531892
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Drug metabolism in pooled human liver microsomes assessed as IC50 for hecogenin-mediated inhibition of anastrozole glucuronidation after 90 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.82 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1399 | ANASTROZOLE | 4.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1399 | ANASTROZOLE | IC50 | = | 15000.0 | nM | 4.82 |