Assay Detail
ADMET
CHEMBL3531950
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Drug metabolism in human liver microsomes assessed as IC50 for docetaxel-mediated inhibition of metabolite formation at 20 uM after 30 mins by LC/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytochrome P450 3A-mediated microsomal biotransformation of 1α,25-dihydroxyvitamin D3 in mouse and human liver: drug-related induction and inhibition of catabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.47 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3542403 | — | — | 1 | 7.92 |
| CHEMBL3542380 | — | — | 1 | 7.42 |
| CHEMBL3542386 | — | — | 1 | 7.42 |
| CHEMBL3351075 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3542403 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3542380 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3542386 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3351075 | — | IC50 | = | 77.0 | nM | 7.11 |