Assay Detail
ADMET
CHEMBL3532208
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Competitive inhibition of CYP2A13 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.00 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.85 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 5.19 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 4.80 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550 | PILOCARPINE | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3989843 | TRANYLCYPROMINE | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL6640 | TRYPTAMINE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL3 | NICOTINE | Ki | = | 72000.0 | nM | 4.14 |