Assay Detail
Binding
CHEMBL3533357
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Inhibition of GCP-2 (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Reversible disulfide formation of the glutamate carboxypeptidase II inhibitor E2072 results in prolonged systemic exposures in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.29 | 9.52 |
| Ki | 1 | 9.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47009 | — | — | 1 | 9.52 |
| CHEMBL2152561 | — | — | 1 | 9.00 |
| CHEMBL303352 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47009 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2152561 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL303352 | — | IC50 | = | 90.0 | nM | 7.05 |