Assay Detail
ADMET
CHEMBL3533583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of OATP2B1-mediated [3H]estrone-3-sulfate uptake in human OATP2B1 expressing HEK293/PDZK1 cells by scintillation counting
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293/PDZK1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 2B1 (CHEMBL1743124) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| Ki | 1 | 5.07 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461101 | ELTROMBOPAG | 4.0 | 2 | 5.07 |
| CHEMBL574431 | SULFOBROMOPHTHALEIN | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461101 | ELTROMBOPAG | Ki | = | 8480.0 | nM | 5.07 |
| CHEMBL461101 | ELTROMBOPAG | Inhibition | - | % | - | |
| CHEMBL574431 | SULFOBROMOPHTHALEIN | Inhibition | - | % | - |