Assay Detail
Functional
CHEMBL3536558
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Inhibition of FGF-stimulated HUVEC cell proliferation assessed as 5-bromo-2-deoxyuridine incorporation
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.08 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377300 | BRIVANIB | 3.0 | 1 | 6.16 |
| CHEMBL427202 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377300 | BRIVANIB | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL427202 | — | IC50 | = | 1011.0 | nM | 6.00 |