Assay Detail
Binding
CHEMBL3538196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant VEGFR-2
4
Total Activities
4
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.41 | 7.58 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSED_COMPOUND_NAME | DOSED_COMPOUND_NAME | - | — | [14C]brivanib alaninate |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377300 | BRIVANIB | 3.0 | 1 | 7.58 |
| CHEMBL3527569 | — | — | 1 | 7.55 |
| CHEMBL3526621 | — | — | 1 | 7.11 |
| CHEMBL3526543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377300 | BRIVANIB | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3527569 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3526621 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3526543 | — | IC50 | > | 30000.0 | nM | - |