Assay Detail
ADMET
CHEMBL3541092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-competitive inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method and Dixon plot
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | 7.00 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1017 | TELMISARTAN | Ki | = | 100.0 | nM | 7.00 |