Assay Detail
Binding
CHEMBL3579137
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Inhibition of Aeromonas veronii metallo-beta-lactamase ImiS expressed in Escherichia coli BL21(DE3) using imipenem substrate pre-incubated for 30 mins by Lineweaver-Burk plot method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aeromonas veronii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azolylthioacetamide: A Highly Promising Scaffold for the Development of Metallo-β-lactamase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.69 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577963 | — | — | 1 | 5.92 |
| CHEMBL3577964 | — | — | 1 | 5.85 |
| CHEMBL3577961 | — | — | 1 | 5.75 |
| CHEMBL3577970 | — | — | 1 | 5.72 |
| CHEMBL3577965 | — | — | 1 | 5.66 |
| CHEMBL3577967 | — | — | 1 | 5.64 |
| CHEMBL3577968 | — | — | 1 | 5.62 |
| CHEMBL3577969 | — | — | 1 | 5.57 |
| CHEMBL3577962 | — | — | 1 | 5.44 |
| CHEMBL3577966 | — | — | 1 | - |
| CHEMBL3577971 | — | — | 1 | - |
| CHEMBL3577972 | — | — | 1 | - |
| CHEMBL3577973 | — | — | 1 | - |
| CHEMBL3577974 | — | — | 1 | - |
| CHEMBL3577975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577963 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3577964 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3577961 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3577970 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL3577965 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3577967 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL3577968 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL3577969 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL3577962 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL3577966 | — | Ki | - | — | - | |
| CHEMBL3577971 | — | Ki | > | 5000000.0 | nM | - |
| CHEMBL3577972 | — | Ki | > | 2500000.0 | nM | - |
| CHEMBL3577973 | — | Ki | - | — | - | |
| CHEMBL3577974 | — | Ki | > | 5000000.0 | nM | - |
| CHEMBL3577975 | — | Ki | - | — | - |