Assay Detail

CHEMBL3579264

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Binding

Inhibition of chymotrypsin-like activity of rabbit 20S proteasome using Suc-LLVY-AMC as substrate after 2 hrs by fluorescence assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Oryctolagus cuniculus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Cystargolides, 20S Proteasome Inhibitors Isolated from Kitasatospora cystarginea.

Gill KA, Berrué F, Arens JC, Carr G, Kerr RG.
J Nat Prod (2015) 78 : 822 -826
PubMed 25769015 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.68	6.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL491636	BELACTOSIN A	—	1	6.68
CHEMBL1783833	BELACTOSIN C	—	1	6.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL491636	BELACTOSIN A	IC50	=	210.0	nM	6.68
CHEMBL1783833	BELACTOSIN C	IC50	=	210.0	nM	6.68