Assay Detail

CHEMBL3579265

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Binding

Inhibition of proteasome (unknown origin)

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Cystargolides, 20S Proteasome Inhibitors Isolated from Kitasatospora cystarginea.

Gill KA, Berrué F, Arens JC, Carr G, Kerr RG.
J Nat Prod (2015) 78 : 822 -826
PubMed 25769015 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.30	8.30
Ki	1	9.22	9.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL325041	BORTEZOMIB	3.0	1	9.22
CHEMBL451887	CARFILZOMIB	4.0	1	8.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL325041	BORTEZOMIB	Ki	=	0.6	nM	9.22
CHEMBL451887	CARFILZOMIB	IC50	=	5.0	nM	8.30