Assay Detail
Binding
CHEMBL3579416
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Inhibition of HIV1 protease PR20 mutant expressed in Escherichia coli BL21 (DE3) incubated for 5 mins followed by Abz-Thr-Ile-Nle-p-nitro-Phe-GlnArg-NH2 substrate addition and measured over 5 mins by microplate reader based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.57 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577575 | — | — | 1 | 8.77 |
| CHEMBL3577576 | — | — | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577575 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3577576 | — | Ki | = | 4.3 | nM | 8.37 |