Assay Detail
Binding
CHEMBL3579429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal hexa-histidine tagged Mycobacterium tuberculosis HGPRT expressed in Escherichia coli BL-21(DE3) using PRib-PP substrate and guanine
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.45 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325754 | — | — | 1 | 6.16 |
| CHEMBL2325752 | — | — | 1 | 6.11 |
| CHEMBL3578115 | — | — | 1 | 5.95 |
| CHEMBL3394316 | — | — | 1 | 5.85 |
| CHEMBL3578110 | — | — | 1 | 5.80 |
| CHEMBL3578114 | — | — | 1 | 5.80 |
| CHEMBL1229838 | — | — | 1 | 5.75 |
| CHEMBL2325753 | — | — | 1 | 5.11 |
| CHEMBL3578112 | — | — | 1 | 4.80 |
| CHEMBL1233207 | — | — | 1 | 4.75 |
| CHEMBL3578111 | — | — | 1 | 4.65 |
| CHEMBL3578113 | — | — | 1 | 4.64 |
| CHEMBL3578109 | — | — | 1 | - |
| CHEMBL3394313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325754 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL2325752 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL3578115 | — | Ki | = | 1130.0 | nM | 5.95 |
| CHEMBL3394316 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3578110 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3578114 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL1229838 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL2325753 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL3578112 | — | Ki | = | 15900.0 | nM | 4.80 |
| CHEMBL1233207 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL3578111 | — | Ki | = | 22500.0 | nM | 4.65 |
| CHEMBL3578113 | — | Ki | = | 22700.0 | nM | 4.64 |
| CHEMBL3578109 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3394313 | — | Ki | > | 50000.0 | nM | - |