Assay Detail
Functional
CHEMBL3579562
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Antiplasmodium activity against chloroquine-resistant intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green I staining-based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Neolignans and other metabolites from Ocotea cymosa from the Madagascar rain forest and their biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.81 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 9.09 |
| CHEMBL3577183 | — | — | 1 | 6.35 |
| CHEMBL3577103 | — | — | 1 | 5.48 |
| CHEMBL3577192 | — | — | 1 | 5.39 |
| CHEMBL3577191 | — | — | 1 | 5.11 |
| CHEMBL3577187 | — | — | 1 | 4.84 |
| CHEMBL3577189 | — | — | 1 | 4.38 |
| CHEMBL3577102 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL3577183 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3577103 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3577192 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3577191 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3577187 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL3577189 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3577102 | — | IC50 | - | — | - |