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Assay Detail

CHEMBL3579881

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of soyabean 5-LOX using arachidonic acid as substrate by microplate scanning spectrophotometer analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Singh P, Prasher P, Dhillon P, Bhatti R.
Eur J Med Chem (2015) 97 : 104 -123
PubMed 25956953 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.47 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3576979 1 8.70
CHEMBL3576974 1 8.40
CHEMBL3576973 1 8.30
CHEMBL3113617 1 8.07
CHEMBL3576988 1 8.00
CHEMBL3576976 1 7.10
CHEMBL3576977 1 7.00
CHEMBL93 ZILEUTON 4.0 1 6.52
CHEMBL3576983 1 6.22
CHEMBL3576986 1 6.10
CHEMBL3576981 1 6.00
CHEMBL16596 QUIFLAPON 2.0 1 5.80
CHEMBL3576975 1 5.63
CHEMBL3576984 1 5.55
CHEMBL3576982 1 5.43
CHEMBL3576978 1 5.25
CHEMBL3576985 1 5.08
CHEMBL3576987 1 4.91
CHEMBL3576980 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3576979 IC50 = 2.0 nM 8.70
CHEMBL3576974 IC50 = 4.0 nM 8.40
CHEMBL3576973 IC50 = 5.0 nM 8.30
CHEMBL3113617 IC50 = 8.6 nM 8.07
CHEMBL3576988 IC50 = 10.0 nM 8.00
CHEMBL3576976 IC50 = 80.0 nM 7.10
CHEMBL3576977 IC50 = 100.0 nM 7.00
CHEMBL93 ZILEUTON IC50 = 300.0 nM 6.52
CHEMBL3576983 IC50 = 600.0 nM 6.22
CHEMBL3576986 IC50 = 800.0 nM 6.10
CHEMBL3576981 IC50 = 1000.0 nM 6.00
CHEMBL16596 QUIFLAPON IC50 = 1600.0 nM 5.80
CHEMBL3576975 IC50 = 2330.0 nM 5.63
CHEMBL3576984 IC50 = 2800.0 nM 5.55
CHEMBL3576982 IC50 = 3700.0 nM 5.43
CHEMBL3576978 IC50 = 5610.0 nM 5.25
CHEMBL3576985 IC50 = 8380.0 nM 5.08
CHEMBL3576987 IC50 = 12220.0 nM 4.91
CHEMBL3576980 IC50 = 15210.0 nM 4.82