Assay Detail
Binding
CHEMBL3579883
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Inhibition of human recombinant COX-2 assessed as PGF2 alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.87 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3576979 | — | — | 1 | 8.20 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.40 |
| CHEMBL3576986 | — | — | 1 | 7.33 |
| CHEMBL1235806 | — | — | 1 | 7.30 |
| CHEMBL3576974 | — | — | 1 | 7.00 |
| CHEMBL3576976 | — | — | 1 | 6.27 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 6.20 |
| CHEMBL3576973 | — | — | 1 | 6.05 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.02 |
| CHEMBL3576984 | — | — | 1 | 6.01 |
| CHEMBL3576978 | — | — | 1 | 6.00 |
| CHEMBL3576980 | — | — | 1 | 5.60 |
| CHEMBL3576983 | — | — | 1 | 5.44 |
| CHEMBL3576987 | — | — | 1 | 5.18 |
| CHEMBL3576982 | — | — | 1 | 5.08 |
| CHEMBL3576981 | — | — | 1 | 5.05 |
| CHEMBL3113617 | — | — | 1 | 5.04 |
| CHEMBL3576977 | — | — | 1 | 4.99 |
| CHEMBL3576985 | — | — | 1 | 4.99 |
| CHEMBL3576988 | — | — | 1 | 4.87 |
| CHEMBL3576975 | — | — | 1 | 4.67 |
| CHEMBL16171 | WOGONIN | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3576979 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL118 | CELECOXIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3576986 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1235806 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3576974 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3576976 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3576973 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3576984 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3576978 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3576980 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3576983 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL3576987 | — | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL3576982 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL3576981 | — | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL3113617 | — | IC50 | = | 9110.0 | nM | 5.04 |
| CHEMBL3576977 | — | IC50 | = | 10340.0 | nM | 4.99 |
| CHEMBL3576985 | — | IC50 | = | 10310.0 | nM | 4.99 |
| CHEMBL3576988 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL3576975 | — | IC50 | = | 21310.0 | nM | 4.67 |
| CHEMBL16171 | WOGONIN | IC50 | = | 46000.0 | nM | 4.34 |